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Immunotherapy transforms lung cancer, the biggest cancer killer

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The results are so startling that it is likely every lung cancer patient should be given the option of immunotherapy first, said Dr. Roy Herbst, a lung cancer specialist at Yale Cancer Center who was not involved in the studies.

“I have never seen progress move so fast,” Herbst told NBC News.

“The results today are really a paradigm shift. They will mean more lung cancer patients getting immunotherapy up front.”

Immunotherapy helps the body’s immune system fight off cancer through a variety of mechanisms: by boosting immune system activity, uncloaking tumor cells and with the use of engineered immune system proteins that very specifically target tumors.

They include the new class of drugs that appear to have stalled former President Jimmy Carter’s melanoma.

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The drugs had been shown to help lung cancer, the No.1 cause of cancer death globally and in the United States.

And the new results, released at an American Association for Cancer Research conference in Chicago and published in the New England Journal of Medicine, show more creative use of the drugs could change the way doctors treat lung cancer.

 Donna Fernandez, now 64, of Dallas, TX says she is alive thanks to immunotherpay cancer drugs. Bill Arscott / American Association for Cancer Research

In one study, a team at Johns Hopkins medical school treated 20 patients with one of the immune therapy drugs before they had surgery to remove lung cancer tumors.

A year later, 16 patients were alive and the cancer was still undetectable. Two more had their cancer come back but now have no symptoms after extra treatment. One died of lung cancer and one died of an unrelated head injury. So a year and a half later, 18 of the lung cancer patients are still alive.

“I have never seen progress move so fast.”

“I have never seen progress move so fast.”

It was a small study but it shows the immunotherapy drugs can help patients straight away, Herbst said. Until now, because the drugs are new, they’re usually used most in patients with advanced cancer.

The immunotherapy drug — in this case it was the one called Opdivo — starts killing the tumor by breaking it up, releasing small pieces that stimulate a broad immune response.

“When the surgeons open the patients, they see the tumor almost melting away. That is extraordinary,” Herbst said.

“It eats it away like a Pac-man. It probably creates a roller coaster of immune response.”

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These newly activated immune cells can move through the body, attacking the little bits of tumor that can cause metastasis, Herbst said.

“It is amazing news for patients with this disease,” he said.

The news is not all good. Not all patients are helped by the drugs and they are very expensive, costing more than $100,000 for a course of treatment.

And no one can say how long these patients will live before their cancer comes back. “I don’t use the term cure until you survive for 10 years,” said Dr. Drew Pardoll of Johns Hopkins, who led the study that used the immune therapy pre-treatment.

In another study, combinations of immunotherapy drugs with standard chemotherapy doubled survival in lung cancer patients.

Dr. Leena Gandhi of the Perlmutter Cancer Center at NYU Langone Health and colleagues treated more than 600 lung cancer patients with standard chemo plus either a placebo or Keytruda, one of the immunotherapy drugs.

“They gave me four months to live and here I still am.”

“They gave me four months to live and here I still am.”

Those who got Keytruda plus chemo were 51 percent less likely to die than those who simply got the chemo, Gandhi’s team reported. About 69 percent of patients who got Keytruda were alive a year later while just 49 percent of those who got chemo alone were.

“Just a few years ago it was rare for patients with advanced lung cancer to live past two years. Now it is becoming more common to live past that point even with advanced lung cancer,” said Dr. John Heymach, who chairs the lung cancer division at the University of Texas MD Anderson Cancer Center.

“Advanced lung cancer is no longer a death sentence for these patients.”

The Keytruda-chemo combination was approved by the Food and Drug Administration last year.

Another study team tried combining two immunotherapy drugs: Opdivo and Yervoy.

Dr. Matthew Hellmann of Memorial Sloan Kettering Cancer Center and colleagues found that 43 percent of the patients who got the combination got an extra year of life without the cancer worsening, compared to 13 percent of those on standard chemo.

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The American Cancer Society projects about 234,030 new cases of lung cancer will be diagnosed in the U.S. this year, and about 154,050 Americans will die from it.

Donna Fernandez of Rowlett, Texas, is alive thanks to immune therapy for her lung cancer. She was diagnosed with stage 4 lung cancer at age 59 and thought she was doomed because her father had died of lung cancer.

Fernandez, 64, tried chemo and hated it. “Chemo is not for the faint of heart,” she told NBC News.

“There was a time when I thought it was maybe not worth it any more,” she said.

“I was only sick for one week out of the three-week cycle. But that one week was horrible. I threw up and the fatigue is just unreal.”

Then in 2013 Fernandez was treated with Opdivo.

“It was like night and day,” she said. “I could go back to just about my regular activities again. I was never sick.”

Fernandez is not cured but she feels well and is using her extra time to enjoy time with her husband of 43 years, her son and her 88-year-old mother and to advocate for lung cancer research. She is headed to a rally in Washington later this month.

“They gave me four months to live and here I still am,” she said.

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German election: ‘Boring’ Olaf Scholz may be just the ticket amid uncertainty about life after ‘Mummy’ Merkel | World News

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Germany is about to lose its political mother and an air of uncertainty clouds the current election to replace her.

They call Angela Merkel “Mutti”, or Mummy, because of her calm reassuring style of rule in crisis after crisis.

For young Germans, she is the only leader they have ever known.

German Chancellor Angela Merkel arrives for a news conference, amidst the coronavirus disease (COVID-19) pandemic, at the Chancellery in Berlin, Germany March 19, 2021. Michael Sohn/Pool via REUTERS
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Germans call Angela Merkel ‘Mutti’ or Mummy because of her reassuring leadership style

We joined a posse of young leafleteers from Ms Merkel’s rivals’ party, the Social Democratic Party.

Emma Otto, freshly back from au pairing in Dulwich, told us losing Mutti will be weird.

“She’s been the only chancellor I’ve known,” she said. “I can’t remember a time before her so I think it’s going to be a really big change.”

They are missing her already.

We spoke to volunteers heading to help victims of July’s devastating floods.

A huge voluntary effort has sprung up in the absence of official help.

Chairwoman of Buendnis 90/Die Gruenen Annalena Baerbock, Prime Minister of North Rhine-Westphalia (NRW) and leader of the Christian Democratic Union (CDU) Armin Laschet and German Finance Minister and Social Democratic Party candidate Olaf Scholz are pictured before a televised debate of the candidates to succeed Angela Merkel as German chancellor in Berlin, Germany, September 12, 2021. Michael Kappeler/Pool via REUTERS
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(L-R) Social Democratic Party leader Olaf Scholz, Alliance 90/The Greens leader Annalena Baerbock and Christian Democratic Union leader Armin Laschet are the election’s top contenders

In its camp, many sounded disillusioned with politics in general.

“It’s a difficult election,” one volunteer told us. “I think none of the candidates is fully convincing.

“Someone was joking if Angela Merkel was still up for election she’d probably win because people would say we’ve seen the alternatives, we’d better stay with what we have.”

Another young voter out handing out leaflets was welcoming change.

Germany's Finance Minister Olaf Scholz attends a news conference after Chancellor Angela Merkel and state premiers reached an agreement with the regions most affected by the planned brown coal exit, in Berlin, Germany, January 16, 2020. REUTERS/Michele Tantussi
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Candidate Olaf Schulz has been described as ‘boring’

“Sixteen years of chancellorship is too much I’d say,” Alicem Polat told Sky News.

“We have our candidate, Olaf Scholz, so we definitely say there is someone to replace her.”

“People say he’s boring,” I interject.

“He is, I admit, but maybe that’s the German way of politics.”

Alicem Polat said Angela Merkel has been chancellor for too long
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Alicem Polat said Angela Merkel has been chancellor for too long

And there’s the rub. The likely next chancellor Olaf Scholz, Germany’s current finance minister, has no political pizzazz or charisma.

But that may be a good thing to voters.

Unsettled by the loss of Ms Merkel and the pandemic, Germans will take quiet, boring competence over excitement.

He is also the last person standing for now at least in the polls.

Ms Merkel’s heir apparent should have been Armin Laschet.

Election posters of Germany's top candidates for chancellor, Armin Laschet, North Rhine-Westphalia's State Premier and Christian Democratic Union (CDU) leader, Olaf Scholz, German Minister of Finance of the Social Democratic Party (SPD), Annalena Baerbock, co-leader of Germany's Green party and Christian Lindner, leader of the Free Democratic Party of Germany (FDP) are pictured, in Berlin, Germany, September 16, 2021. REUTERS/Fabrizio Bensch
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(L-R) Election posters of Armin Laschet, Olaf Scholz, Annalena Baerbock and Christian Lindner

But the new Christian Democratic Union leader has slipped on a banana skin thrown up by recent disastrous floods.

In the background, while dignitaries made speeches honouring the floods’ victims, Mr Laschet was caught on camera sniggering.

His standing took a beating in the polls.

So much for the CDU.

Christian Democratic Union (CDU) candidate for chancellor Armin Laschet holds a news conference in Berlin, Germany, September 13, 2021. REUTERS/Michele Tantussi
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CDU candidate Armin Laschet was caught on camera laughing while dignitaries made speeches about flooding victims. File pic

The floods should have been a godsend for the Greens, clear evidence of the dangers of climate change.

And yet Annalena Baerbock, their leader, has been unable to sustain an early lead in the polls.

Accused of plagiarism and lack of experience, she has floundered ever since.

So for now Mr Scholz remains the favourite to win the lion’s share of the vote, giving him the chance to build a coalition.

Max Meyer, political scientist at Bonn University, told Sky News his alleged lack of personality may be just what Germany needs.

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July: Angela Merkel meets the Queen during her visit to the UK

“That makes him probably a better leader,” he said.

“Because it’s more pragmatic and it’s not the theatrics or the big flashiness of charisma, but it’s more policy issues and it’s more policy-driven.”

He may be what Germany wants after Ms Merkel, but the shoes he has to fill are enormous if he wins.

Max Meyer said Olaf Schulz's lack of personality may be just what Germany needs
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Max Meyer said Olaf Schulz’s lack of personality may be just what Germany needs

Ms Merkel rode out the euro crisis, the migrants crisis, the financial crisis and handled autocrats and allies with a firm fairness that soothed tensions and protected German interests.

“I think Germany is going to be very soon nostalgic,” said Mr Meyer, “and probably most will look back with very positive feelings because she was capable of managing crisis and of portraying the country still as stable.”

Germans are going to miss their Mutti.

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Piers Morgan joining new channel talkTV where he will present ‘global show’ | Ents & Arts News

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Piers Morgan has revealed his next presenting job will be for new television channel talkTV – which is being set up by Rupert Murdoch’s News Corp.

The company, which will launch its new service next year, said Morgan’s nightly show will be broadcast in the UK, the US and Australia.

He left Good Morning Britain earlier in the year, after criticising Harry and Meghan’s comments in an interview they gave with Oprah Winfrey, saying he did not believe some of the things they said, particularly around mental health.

The show was recently cleared by Ofcom, after tens of thousands of complaints were made about it.

Talking about his new role, Morgan said: “I’m thrilled to be returning to News Corp, which is where I began my media career more than 30 years ago.

“Rupert Murdoch has been a constant and fearless champion of free speech and we are going to be building something new and very exciting together.

“I want my global show to be a fearless forum for lively debate and agenda-setting interviews, and a place that celebrates the right of everyone to have an opinion, and for those opinions to be vigorously examined and challenged.

“I’m also delighted to become a columnist for The Sun and the New York Post, two brilliantly successful and popular newspaper brands.

“I’m going home and we’re going to have some fun.”

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‘A good day for free speech’ – Piers Morgan

Executive chairman of News Corp, Rupert Murdoch, added: “Piers is the broadcaster every channel wants but is too afraid to hire. Piers is a brilliant presenter, a talented journalist and says what people are thinking and feeling.”

In the past, Morgan has been hired by ITV, CNN and NBC in various presenting roles.

News Corp said its new channel will “offer a mix of programming from our stable of household brands, proper hourly news bulletins, documentaries, entertainment and more”.

The company already owns established news brands such as The Times and The Sun newspapers, as well as a number of radio stations such as Virgin and talkSport.

News Corp had previously scrapped plans for a linear news channel, and instead decided to focus on streaming its radio brands online, while rival GB News pushed ahead with its launch.

Responding to News Corp’s announcement, GB News tweeted: “Congratulations to Piers Morgan.

“We love competition. Bring it on!”

In the US, Morgan’s show will be carried on Fox Nation, while Sky News Australia will broadcast it down under.



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China says AUKUS submarine deal ‘highly irresponsible’ and ‘intensifies the arms race’ | World News

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A new security deal between the United States, Britain, and Australia in the Indo-Pacific “severely damages regional peace” and “intensifies the arms race”, China has said.

On Wednesday, the three western powers announced they will establish a security partnership that will help Australia acquire US nuclear-powered submarines.

In Beijing, Chinese Foreign Ministry spokesman Zhao Lijian condemned the move and said: “The US, the UK and Australia’s cooperation in nuclear submarines severely damages regional peace and stability, intensifies the arms race, and jeopardises the international efforts in promoting the non-proliferation of nuclear weapons.

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‘AUKUS alliance will bring us closer than ever’

“The US and UK’s action of exporting highly sensitive nuclear submarine technology once again proves that they are using nuclear exports as a tool for geopolitical games and adapts double standards.

“This is a highly irresponsible act.”

It comes as France accused US President Joe Biden of stabbing it in the back and acting like predecessor Donald Trump after Paris was snubbed from a $40bn (£29bn) defence deal it had signed with Australia.

The deal, dubbed AUKUS, will see Australia scrap its 2016 agreement with French shipbuilder Naval Group to build a new fleet to replace its ageing Collins submarines.

“This brutal, unilateral and unpredictable decision reminds me a lot of what Mr Trump used to do,” foreign minister Jean-Yves Le Drian said on franceinfo radio.

“I am angry and bitter. This isn’t done between allies.”

“It’s a stab in the back. We created a relationship of trust with Australia and that trust has been broken,” he added.

He had previously said in a statement the “choice to exclude a European ally and partner such as France” was something the country “can only note and regret”.

London, Canberra and Washington have said they will seek to collaborate in cyber, quantum technologies and artificial intelligence, as well as other underwater capabilities.

Defence Secretary Ben Wallace told Sky News on Thursday: “We have no intention of doing anything to antagonise the French – the French are some of our closest military allies in Europe, we are sizable and comparable forces and we do things together.”

He added: “The French were contracted to deliver diesel submarines and the Australians took a decision they wanted to switch out of that and into nuclear.

“Each country has to make those choices in their own national security interests.”

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Did Biden forget Australian PM’s name?

Nuclear-powered submarines are superior to their diesel counterparts as they can operate more quietly and stay underwater for longer.

How the collaboration will work, what it will cost, how many boats will be built, where and which companies will be involved has not yet been revealed.

However, just two weeks ago the Australian defence and foreign ministers had reconfirmed the deal to their French counterparts.

But the agreement had been beset with issues and delays, due to Canberra’s requirement the majority of manufacturing and components be sourced locally.

Mr Biden said France remained a “key partner in the Indo-Pacific zone”, while Australian Prime Minister Scott Morrison said his country looked forward to continuing to work “closely and positively” with the French, adding: “France is a key friend and partner to Australia and the Indo-Pacific.”

In a joint statement, the pair along with Britain’s Prime Minister Boris Johnson said: “The endeavour we launch today will help sustain peace and stability in the Indo-Pacific region.

“For more than 70 years, Australia, the United Kingdom, and the US have worked together, along with other important allies and partners, to protect our shared values and promote security and prosperity. Today, with the formation of AUKUS, we recommit ourselves to this vision.”

Although the word “China” was not mentioned specifically, the predominant security and defence challenge in the region is the rise of an increasingly assertive, authoritarian Beijing.

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